Podcast

Is doing a PhD in worth it? From Brown Sludge to Breakthroughs

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Are you thinking about pursuing a PhD in chemistry and have wondered if its with the struggle? In this episode of ‘Innovate and React’, we discuss the personal and professional journey of pursuing a PhD and share our motivations for studying chemistry. We discuss the challenges and surprises encountered during our PhD journey, and the important skills we developed through teaching and research. Every journey is different and depends on many different things. We give a glimpse into our experience with doing a PhD in chemistry and how it can be worth it.

Challenging HSAB: Reactive Molecules and Nucleophiles

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In this episode of Innovate and React, I am talking with Justus Reitz, a chemist from TU Dortmund University, about the limitations of the HSAB (Hard and Soft Acids and Bases) concept in predicting reaction outcomes. We explore an alternative approach using the nucleophilicity scale developed by the Mayr group, which offers a more accurate prediction method. Justus shares insights from his PhD research on stabilizing highly reactive molecules, particularly the synthesis and stabilization of diazoalkenes. We discuss how the Mayr nucleophilicity scale can facilitate understanding and controlling chemical reactions, bridging the gap between theoretical concepts and practical applications.
For more check out innovateandreact.com

Beyond Gold: Exploring Acid-Promoted Cyclization in Organic Chemistry

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How can we make pharmaceutical synthesis greener and more efficient? In this episode of Innovate and React, we dive into the world of organic chemistry with Dr. Nikolas Jankowski to explore an alternative to gold catalysis. While gold catalysts are known for their high selectivity and efficiency, their cost, environmental impact, and challenges in industrial applications call for new solutions.
Nick shares his research on acid-promoted cyclization using hexafluoroisopropanol (HFIP) as a unique solvent, mimicking some of the effects of metal catalysts. We discuss the breakthroughs that led to a more efficient synthesis of oxazoles, molecules with promising pharmaceutical applications.
Tune in as we uncover the intersection of fundamental research, reaction optimization, and the future of sustainable chemistry.

How ion-exchange resins can make a reaction more sustainable

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This episode provided a deep dive into how ion exchange resins could revolutionize aldol reactions, making them greener and more sustainable. While traditional catalysts like sodium hydroxide are cheap, their environmental and economic drawbacks make alternative solutions necessary. Ion exchange resins, particularly those with improved linker stability, show promise, though challenges like clogging must be addressed before industrial adoption.

The discussion underscored the broader importance of catalysis in chemical research and industry, particularly in reducing waste, energy consumption, and process costs. As research progresses, these insights could lead to more efficient and sustainable chemical production methods, aligning with the goals of green chemistry. En example is the aldol reaction, an essential process in the chemical industry for producing pseudo-ionone, a precursor for vitamin A. This reaction was used as the model reaction, to investigate the ion-exchange resins as possible heterogeneous catalysts.

Innovate and react Introduction

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This Episode give a short introduction into the future content of the podcast.

For more informations visit www.innovateandreact.com, where you will find all episode and additional content for each episode.

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