Organic chemistry

Turning Methane into Value-Chemicals via Photocatalysis

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In this episode we discuss a novel and sustainable approach to converting methane into valuable chemicals. Currently light hydrocarbons like methane are often simply burned for energy, despite their potential as a carbon source for the chemical industry. Traditional conversion methods like natural gas cracking are energy-intensive, and other functionalization routes require harsh conditions and often toxic chemicals. Dr. Andrés Constantino sharess his research focusing on photocatalysis to achieve the direct functionalization of methane under milder conditions.
The key to this method is a supramolecular catalytic system using FeCl3•6H2O and collidine. When irradiated, the catalyst generates a highly active chlorine radical that efficiently abstracts hydrogen from the inert alkane (methane) to form an alkyl radical. The collidine plays a crucial dual role, acting as a base to quench the resulting HCl and as a ligand that stabilizes the iron tetrachloride core. The radicals were used for allylation chemistry, which retains a useful olefin group in the product.

How metal organic complexes can shape your electronic devices

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In this episode of Innovate and React, Dr. Leonardo Santoni, a postdoctoral researcher at UCL and a science content creator, shares his insights into the fascinating world of metal-organic precursors for low-temperature metal deposition. He presents his PhD research on aluminum complexes for printed electronics, highlighting the challenges of precursor design, deposition techniques, and the potential of sustainable and user-friendly alternatives to pyrophoric materials. In the second part Leonardo gives his opinion on science communication how short form videos can make chemistry accessible for a broader audience.

Challenging HSAB: Reactive Molecules and Nucleophiles

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In this episode of Innovate and React, I am talking with Justus Reitz, a chemist from TU Dortmund University, about the limitations of the HSAB (Hard and Soft Acids and Bases) concept in predicting reaction outcomes. We explore an alternative approach using the nucleophilicity scale developed by the Mayr group, which offers a more accurate prediction method. Justus shares insights from his PhD research on stabilizing highly reactive molecules, particularly the synthesis and stabilization of diazoalkenes. We discuss how the Mayr nucleophilicity scale can facilitate understanding and controlling chemical reactions, bridging the gap between theoretical concepts and practical applications.
For more check out innovateandreact.com

Beyond Gold: Exploring Acid-Promoted Cyclization in Organic Chemistry

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How can we make pharmaceutical synthesis greener and more efficient? In this episode of Innovate and React, we dive into the world of organic chemistry with Dr. Nikolas Jankowski to explore an alternative to gold catalysis. While gold catalysts are known for their high selectivity and efficiency, their cost, environmental impact, and challenges in industrial applications call for new solutions.
Nick shares his research on acid-promoted cyclization using hexafluoroisopropanol (HFIP) as a unique solvent, mimicking some of the effects of metal catalysts. We discuss the breakthroughs that led to a more efficient synthesis of oxazoles, molecules with promising pharmaceutical applications.
Tune in as we uncover the intersection of fundamental research, reaction optimization, and the future of sustainable chemistry.

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